A positive Signatera™ result predicts relapse with overall positive predictive value more than 98%
The Signatera™ test is a highly sensitive and personalized molecular residual disease (MRD) test that uses circulating tumor DNA (ctDNA) for analysis.
Unique molecular genetic test from blood samples
Accurate result in early detection of tumor recurrence
Influences further anti-cancer treatment
Signatera™ can be used for all solid tumor types
The Signatera™ test can detect molecular residual disease (MRD), and with early recognition of MRD, recurrence can be identified earlier, thereby increasing the effectiveness of anti-cancer treatment and improving survival. The Signatera™ test is custom designed for each patient to help identify relapse earlier than standard imaging procedures.
World-class diagnostics
In clinical studies, the Signatera™ test has demonstrated outstanding sensitivity in detecting cancer recurrence in all solid tumors.
How the Signatera™ test works
Learn more about how the Signatera™ test Works
Blood test
A blood test is required to perform the Signatera™ test and for further follow-up tests to assess the change in ctDNA levels over time.
MRD test based on your own tissue sample
To identify ctDNA, we first determine the tumor’s unique set of mutations based on the patient’s own histology sample. These unique mutations help create the custom-designed, personalized Signatera™ test
Detection of circulating tumor DNA in the blood
By detecting ctDNA it is possible to determine whether tumor cells are still present in the body, after completed anti-cancer treatment or during follow-up.
Molecular monitoring of malignant tumors
– a new, innovative, personalized method of medicine
„Detecting relapse before it becomes clinically symptomatic requires a test with high sensitivity and specificity.
Signatera enables us to confidently identify patients with molecular relapse when the disease burden is so low that it is undetectable with imaging“ – Pusztai Lajos, MD, DPhil
Personalized: follow-up based on the unique DNA pattern of the patient’s own tumor tissue
Sensitive: Detects recurrence with up to 98% accuracy by detecting the tumor’s unique “fingerprint”
Long–term follow–up: Personalized care after completion of anti-cancer therapies
Regular free information
For those interested in testing, our geneticists regularly provide online information where patients can ask questions.
Find your nearest blood collection point
Blood sampling is available after prior consultation not only in Budapest, but also in rural towns. You can find out about our sampling locations here.
Frequently Asked Questions (FAQ)
Based on our experience, we have collected the most frequently asked questions about the Signatera™ test. Read the questions and answers here.
Tumour markers are biochemical substances selectively produced by tumour cells that can be detected in the blood or other body fluids. Tumour markers are not the most suitable for screening due to their sensitivity, they are only confirmatory in themselves, as their accuracy is much lower than the Signatera™ test. So what the Signatera™ test detects, tumour marker tests may not be able to detect.
Not yet available. A particular diagnostic test takes a long time to be accepted for funding. In such cases, individual applications are possible.
The test can be performed in all solid tumours, regardless of stage. Simply put, a solid tumour is a tumour that does not originate from “blood cells”. It can be said that almost any tumour type other than haematological tumours fits the definition. Thus, there is a wide range where it can be applied.
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Have a question? Wondering if the Signatera™ test is right for you?
Contact us and we will answer your questions as soon as possible.
